Event | No. of trials reporting the event | SSRI | Placebo | Relative risk (95% CI) | Number needed to harm (NNH) | P value | ||
---|---|---|---|---|---|---|---|---|
Number of participants with the event | Number of participants randomised | Number of participants with the event | Number of participants randomised | |||||
Abnormal ejaculation | 15 | 183 | 3236 | 7 | 1903 | 5.43 [3.22, 9.14] | 19 | P < 0.00001 |
Tremor | 28 | 301 | 3502 | 61 | 2929 | 3.16 [2.37, 4.21] | 16 | P < 0.00001 |
Anorexia | 19 | 220 | 2350 | 42 | 1680 | 2.78 [2.03, 3.79] | 15 | P < 0.00001 |
Nausea | 78 | 2524 | 12,257 | 779 | 8491 | 2.48 [2.22, 2.77] | 9 | P < 0.00001 |
Somnolence | 59 | 1336 | 10,351 | 345 | 6674 | 2.25 [2.00, 2.53] | 13 | P < 0.00001 |
Sweating | 34 | 440 | 5274 | 124 | 3478 | 2.20 [1.80, 2.70] | 21 | P < 0.00001 |
Asthenia | 23 | 497 | 3968 | 155 | 2265 | 1.71 [1.43, 2.04] | 18 | P < 0.00001 |
Diarrhoea | 58 | 1458 | 11,056 | 561 | 7099 | 1.66 [1.51, 1.83] | 19 | P < 0.00001 |
Constipation | 50 | 606 | 6698 | 273 | 4892 | 1.60 [1.35, 1.89] | 29 | P < 0.00001 |
Insomnia | 69 | 1500 | 11,934 | 582 | 7956 | 1.49 [1.35, 1.64] | 19 | P < 0.00001 |
Dizziness | 55 | 849 | 8900 | 398 | 6161 | 1.39 [1.24, 1.57] | 33 | P < 0.00001 |
Dry mouth | 73 | 1376 | 11,303 | 693 | 7904 | 1.37 [1.25, 1.49] | 30 | P < 0.00001 |
Libido decreased | 8 | 78 | 1481 | 11 | 1083 | 3.48 [1.92, 6.32] | 24 | P < 0.0001 |
Sexual dysfunction | 6 | 96 | 719 | 16 | 389 | 2.85 [1.77, 4.59] | 11 | P = 0.0001 |
Appetite decreased | 8 | 68 | 932 | 24 | 885 | 2.63 [1.66, 4.17] | 22 | P < 0.0001 |
Fatigue | 26 | 409 | 5098 | 153 | 3545 | 1.69 [1.32, 2.17] | 27 | P < 0.0001 |
Vomiting or upset stomach | 20 | 189 | 2376 | 101 | 2037 | 1.55 [1.16, 2.08] | 34 | P = 0.003 |
Flu syndrome | 7 | 57 | 1069 | 19 | 822 | 2.13 [1.28, 3.54] | 34 | P = 0.004 |
Drowsiness | 5 | 38 | 253 | 19 | 256 | 1.90 [1.18, 3.04] | 14 | P = 0.004 |
Blurred/abnormal vision or dry eyes | 17 | 116 | 1862 | 55 | 1566 | 1.55 [1.15, 2.10] | 37 | P = 0.004 |
Nervousness | 22 | 484 | 3863 | 147 | 2043 | 1.35 [1.10, 1.66] | 19 | P = 0.004 |
Back pain | 11 | 85 | 2404 | 71 | 1594 | 0.66 [0.48, 0.91] | 109 | P = 0.01 |
Headache | 72 | 2386 | 11,085 | 1427 | 7805 | 1.08 [1.01, 1.14] | 31 | P = 0.02 |
Dyspepsia | 23 | 331 | 4304 | 159 | 2956 | 1.29 [1.04, 1.59] | 44 | P = 0.02 |
Weight loss | 3 | 26 | 562 | 9 | 560 | 2.48 [1.17, 5.25] | 34 | P = 0.02 |
Hypertension | 4 | 17 | 933 | 25 | 761 | 0.51 [0.28, 0.93] | 69 | P = 0.03 |
Central or peripheral nervous system | 4 | 104 | 221 | 16 | 57 | 1.58 [1.03, 2.43] | 6 | P = 0.04 |
Lightedness/faint feeling | 3 | 9 | 147 | 1 | 144 | 4.81 [1.06, 21.72] | 19 | P = 0.04 |
Accidental injury | 3 | 15 | 672 | 23 | 516 | 0.50 [0.25, 0.99] | 45 | P = 0.05 |
Agitation | 5 | 67 | 613 | 22 | 398 | 1.60 [1.01, 2.54] | 19 | P = 0.05 |
Impotence | 3 | 19 | 868 | 1 | 603 | 3.12 [0.99, 9.88] | 50 | P = 0.05 |
Taste perversion | 2 | 9 | 389 | 1 | 390 | 5.80 [1.02, 33.03] | 49 | P = 0.05 |
Shaking | 2 | 7 | 121 | 0 | 116 | 7.19 [0.91, 57.03] | 18 | P = 0.06 |
Rhinitis | 14 | 197 | 3004 | 171 | 1969 | 0.78 [0.63, 0.97] | 47 | P = 0.06 |
Palpitations | 10 | 63 | 1572 | 30 | 1292 | 1.55 [0.97, 2.50] | 60 | P = 0.07 |
Infection | 7 | 104 | 997 | 57 | 612 | 1.31 [0.97, 1.75] | 90 | P = 0.08 |
Amnesia | 2 | 5 | 484 | 12 | 486 | 0.44 [0.16, 1.20] | 70 | P = 0.11 |
Psychiatric adverse effects | 1 | 19 | 40 | 7 | 26 | 1.76 [0.87, 3.60] | 5 | P = 0.12 |
Sleep distrurbance | 3 | 15 | 240 | 7 | 223 | 1.98 [0.83, 4.73] | 33 | P = 0.13 |
Sinusitis | 4 | 35 | 751 | 38 | 629 | 0.69 [0.43, 1.11] | 73 | P = 0.13 |
Urinary frequency | 4 | 40 | 695 | 19 | 624 | 1.80 [0.82, 3.96] | 37 | P = 0.13 |
Anxiety | 17 | 150 | 2983 | 89 | 2250 | 1.27 [0.91, 1.77] | 94 | P = 0.15 |
Appetie increased | 3 | 5 | 335 | 10 | 330 | 0.49 [0.17, 1.43] | 65 | P = 0.19 |
Coughing | 1 | 8 | 100 | 4 | 96 | 1.92 [0.60, 6.17] | 27 | P = 0.27 |
Tinnitus | 2 | 4 | 319 | 1 | 319 | 2.84 [0.44, 18.44] | 107 | P = 0.27 |
Adverse events overall | 4 | 32 | 232 | 14 | 160 | 1.36 [0.77, 2.39] | 20 | P = 0.29 |
Unpleasant taste | 1 | 2 | 21 | 0 | 20 | 4.77 [0.24, 93.67] | 11 | P = 0.30 |
Congestive heart failure | 1 | 0 | 335 | 2 | 336 | 0.20 [0.01, 4.16] | 168 | P = 0.30 |
Gastrointestial | 4 | 66 | 194 | 14 | 91 | 1.53 [0.65, 3.62] | 6 | P = 0.33 |
Autonomic nervous system | 1 | 10 | 40 | 4 | 26 | 1.63 [0.57, 4.64] | 11 | P = 0.36 |
Respiratory disorder | 10 | 244 | 2764 | 107 | 1276 | 0.90 [0.73, 1.12] | 227 | P = 0.36 |
Vasodialtion | 4 | 11 | 368 | 4 | 355 | 1.75 [0.44, 6.94] | 54 | P = 0.43 |
Flatulence | 6 | 94 | 1763 | 34 | 972 | 1.24 [0.72, 2.16] | 55 | P = 0.44 |
Malaise | 1 | 0 | 21 | 1 | 20 | 0.32 [0.01, 7.38] | 20 | P = 0.48 |
Depression aggrevated | 1 | 6 | 337 | 1 | 180 | 1.95 [0.31, 12.35] | 82 | P = 0.48 |
Female genital disorders | 1 | 7 | 310 | 1 | 149 | 1.93 [0.31, 12.10] | 63 | P = 0.48 |
Weight gain | 1 | 3 | 129 | 5 | 129 | 0.60 [0.15, 2.46] | 65 | P = 0.48 |
Tachycardia | 6 | 9 | 989 | 6 | 996 | 1.43 [0.52, 3.96] | 326 | P = 0.49 |
Arrhythmia | 1 | 0 | 335 | 1 | 336 | 0.33 [0.01, 8.18] | 336 | P = 0.50 |
Atrial fibrillation | 1 | 1 | 335 | 0 | 336 | 3.01 [0.12, 73.60] | 335 | P = 0.50 |
Abnormal electrocardiogram | 1 | 1 | 335 | 0 | 336 | 3.01 [0.12, 73.60] | 335 | P = 0.50 |
Migraine | 1 | 1 | 129 | 0 | 129 | 3.00 [0.12, 72.96] | 129 | P = 0.50 |
Chest discomfort | 1 | 1 | 21 | 0 | 20 | 2.86 [0.12, 66.44] | 21 | P = 0.51 |
Rash | 5 | 9 | 280 | 12 | 282 | 0.79 [0.37, 1.70] | 97 | P = 0.55 |
Vertigo | 1 | 10 | 337 | 3 | 180 | 1.58 [0.32, 7.68] | 77 | P = 0.57 |
Dysuria | 1 | 2 | 21 | 1 | 20 | 1.90 [0.19, 19.40] | 23 | P = 0.58 |
Pruritus (Itching) | 3 | 8 | 187 | 10 | 185 | 0.79 [0.30, 2.10] | 89 | P = 0.63 |
Orthostatic hypotension | 2 | 6 | 466 | 3 | 309 | 1.37 [0.37, 5.02] | 316 | P = 0.64 |
Upper respiratory tract infection | 14 | 164 | 2380 | 123 | 1882 | 0.95 [0.75, 1.20] | 282 | P = 0.68 |
Body as a whole | 1 | 6 | 40 | 3 | 26 | 1.30 [0.36, 4.75] | 29 | P = 0.69 |
Loose stools | 1 | 3 | 100 | 2 | 96 | 1.44 [0.25, 8.43] | 110 | P = 0.69 |
Gastritis | 1 | 3 | 62 | 5 | 138 | 1.34 [0.33, 5.41] | 83 | P = 0.69 |
Cardiovascular disorder | 2 | 10 | 444 | 3 | 355 | 0.81 [0.22, 2.95] | 72 | P = 0.75 |
Pain | 5 | 65 | 893 | 59 | 729 | 0.95 [0.68, 1.34] | 123 | P = 0.77 |
Abnormal thinking | 1 | 7 | 335 | 8 | 336 | 0.88 [0.32, 2.39] | 344 | P = 0.80 |
Abnormal acne | 1 | 3 | 32 | 1 | 14 | 1.31 [0.15, 11.54] | 45 | P = 0.81 |
Confusion | 4 | 5 | 640 | 5 | 621 | 0.87 [0.28, 2.74] | 4187 | P = 0.81 |
Myalgia | 5 | 34 | 692 | 26 | 572 | 0.93 [0.45, 1.94] | 272 | P = 0.85 |
Irritability | 6 | 18 | 643 | 20 | 642 | 0.92 [0.38, 2.27] | 317 | P = 0.86 |
Numbness | 2 | 12 | 272 | 8 | 269 | 0.77 [0.04, 13.27] | 70 | P = 0.86 |
Abdominal pain | 9 | 98 | 1967 | 52 | 1150 | 1.02 [0.73, 1.44] | 218 | P = 0.89 |
Trauma | 2 | 47 | 883 | 14 | 267 | 0.95 [0.41, 2.20] | 1261 | P = 0.90 |
Eructation (burping) | 1 | 5 | 100 | 5 | 96 | 0.96 [0.29, 3.21] | 480 | P = 0.95 |
Over sedation | 3 | 24 | 677 | 7 | 514 | 1.91 [0.83, 4.39] | 46 | P =0.13 |